发明名称 |
VALPROATE CONJUGATION USING DICARBONYLS |
摘要 |
<p>?-substituted derivatives of valproic acid are provided for conjugation to antigenic compositions, particularly poly(amino acids). and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of valproate, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of valproate. The compounds are synthesized by alkylating valproate at the tertiary carbon atom by an aliphatic chain with a terminal double bond which is cleaved to provide an acid or aldehyde group.</p> |
申请公布号 |
CA1160218(A) |
申请公布日期 |
1984.01.10 |
申请号 |
CA19800356274 |
申请日期 |
1980.07.15 |
申请人 |
LEUNG, DANTON K.;SINGH, PRITHIPAL |
发明人 |
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分类号 |
C07K2/00;C07K16/00;C12Q1/26;G01N33/53;G01N33/531 |
主分类号 |
C07K2/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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