| 摘要 |
PURPOSE:To obtain the titled antigen separated from the component of cancer cell membrane, acting to the host as an immunogen, and having extremely high immunogenicity of establish the specific immunoresponce to cancer cell. CONSTITUTION:The cell membrane component is separated from the human or animal cancer cell such as cultured cancer cell, transplanted cancer cell, spontaneously generated cancer call, etc. The component is subjected to the affinity chromatography using a column carrier containing a lectin which bonds specifically with terminal galactose (e.g. peanut lectin, soybean lectin, etc.) or a lectin which bonds specifically with terminal N-acetylgalactosamine (e.g. dolichos bean lectin, osage orange lectin, etc.) to separate the objective sugar chain-relating antigen (GRA) originated from cancer cell. When lymphocyte is sensitized with the GRA, a killer cell which acts specifically to cancer cell containing GRA is obtained, and accordingly, the cancer cell containing GRA is affected and destroyed by the administration of the antigen which recognizes the GRA. |
