ASCOCHLORIN DERIVATIVES,PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

NEW MATERIAL:An ascochlorin derivative expressed by formulaI[R is H or lower alkyl;(n) is an integer 1-5]. EXAMPLE:The compound expressed by formula II. USE:A medicine, capable of enhancing the action of insulin, and having improving action on lipid metabolism and inhibitory action on the growth of experimental tumors. PROCESS:A monometallic salt of ascochlorin is reacted with an ester of a monohalogenated fatty acid in a solvent, e.g. dimethylformamide, at room temperature-the boiling point of the solvent, and if necessary the reaction product is hydrolyzed to afford the aimed compound expressed by formulaI.