发明名称 |
Process for the preparation of antibodies |
摘要 |
A novel peptide of the formula H-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH is the 16-29 fragment of glucagon and can be conjugated with a protein such as albumin or modified albumin using glutaraldehyde or 3-(2'-benzothiazolyl-dithio) propionate succinimide ester as a conjugation reagent. The conjugated peptide can be used to sensitize a mammal by administering the conjugated peptide subcutaneously, after which the blood is collected from the mammal and antibodies concentrated from the blood, which antibodies are then useful in assay methods for trace amounts of glucagon in human blood.
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申请公布号 |
US4423034(A) |
申请公布日期 |
1983.12.27 |
申请号 |
US19820372824 |
申请日期 |
1982.04.28 |
申请人 |
TOYO JOZO KABUSHIKI KAISHA |
发明人 |
NAKAGAWA, NOBUAKI;KOTANI, KIKUO;KATSURAGI, SHIGEO;MORITA, KAORU;OHYAMA, KUNIO;NODA, TOSHIHARU |
分类号 |
C07K14/605;(IPC1-7):A61K39/00;C07G7/00;C07C103/52 |
主分类号 |
C07K14/605 |
代理机构 |
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地址 |
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