| 摘要 |
PURPOSE:To obtain the titled compound easily and efficiently without causing side reactions, by reacting a trifluoromethylhalogenobenzene with copper cyanide in a specific solvent and cupric bromide. CONSTITUTION:A trifluoromethylhalogenobenzene of formula I (X is halogen; Y is H, lower alkyl, etc.) is reacted with copper cyanide in at least one solvent selected from hexamethylphosphoramide (HMPA) and N-methylpyrrolidone (NMP) in the presence of cupric bromide in a molar amount of 0.3-1 of that of the raw material at 100-250 deg.C under ordinary pressure for 1-10hr to give the aimed substance of formula II. When HMPA is used as a solvent, almost the same yield as in the use of the cuprous bromide is obtained. When more inexpensive NMP than HMPA is used, remarkably improved yield of the aimed substance is obtained. The cupric bromide to be used in an amount of about half of the cuprous bromide is sufficient. |
