发明名称 |
FOERFARANDE FOER FRAMSTAELLNING AV 1-ALKYL- ELLER 1,4-DIALKYL-1H-PYRROL-2-AETTIKSYRAESTRAR |
摘要 |
The invention relates to a new process for the preparation of 1-alkyl- or 1,4-dialkyl-1H-pyrrole- -2-acetic acid, esters of the general formula (I) < IMG > (I) wherein R1 is hydrogen or an alkyl group having from 1 to 4 carbon atoms, R2 and R3 each independently represent an alkyl group having from 1 to 4 carbon atoms, by selective desalkoxycarbonylation of the corresponding 1-alkyl- and 1,4-dialkyl-3-alkoxycarbonyl-1H-pyrrole- -2-acetic acid esters of the general formula (II) < IMG > (II) wherein R1, R2 and R3 have the same meaning as defined above, by heating in the presence of a concentrated mineral acid or an aliphatic or aromatic sulfonic acid. Compounds of the general formula (I) are known pharmaceutically active materials, which can be prepared by this process in a single reaction step selectively, without the formation of by-products. |
申请公布号 |
FI832262(L) |
申请公布日期 |
1983.12.23 |
申请号 |
FI19830002262 |
申请日期 |
1983.06.21 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T |
发明人 |
AGAI,(CSONGOR), EVA;HARSANYI, KALMAN;DOMANY, GYOERGY;MAJOR(FORSTNER), PIROSKA;MOLNAR, KAROLY;SZOELLOESY, MARTA;KRUZICS(LAUKO), ANNA |
分类号 |
C07D207/337;A61K31/40;C07D;C07D207/323;C07D207/34 |
主分类号 |
C07D207/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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