LIPOSOMEN MIT INHALATIVEN ALLERGENEN ZUR BEHANDLUNG VON ALLERGIEN, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE ENTHALTENDE ARZNEIMITTEL.

摘要

(A) Liposomes contg. inhalative allergens or allergen fractions in their aqueous compartments are new. new are medicaments contg. liposomes which incorporate inhalative allergens or allergen fractions. Pref. liposomes are formed from diacylglycerolethanolamines with 8-24 C-atoms in the aliphatic acyl group and/or lecithins or lecithin derivs. of formula (I): (where R1 is 8-24C aliphatic acyl; R2 is 1-8C alkyl or 8-24C aliphatic acyl; and the groups -OR1, -OR2 and -OPO3CH2CH2N(CH3)s can be exchanged with each other), optionally, in the presence of di(8-24C aliphatic acyl)glycerophosphoric acid esters and/or adjuvant lysolecithins corresponding to formula (I) in which R2 is replaced by H and/or of cholesterols; the aqueous compartment consisting of the allergens or allergen fractions in an isotonic phosphate buffer.