| 摘要 |
<p>Process for the preparation of a 4-hydroxyquinoline of the formula: <IMAGE> in which R represents a hydrogen atom or one, two or three substituents, which may be the same or different, selected from halogen atoms, alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms, and the trifluoromethyl radical, the substituent(s) being in the 2-, 3-, 5-, 6-, 7- or 8-position, which comprises oxidizing a 1,2,3,4-tetrahydroquinolin-4-one of the general formula: <IMAGE> in which R is as hereinbefore defined, in a basic medium, under pressure, by means of excess oxygen or air at a temperature between 80 DEG and 150 DEG C. The 4-hydroxyquinoline products are useful for the preparation of therapeutically useful substances.</p> |
