PREPARATION OF FLUORINATED METHYL AMINOALKANOIC ACIDS AND NOVEL PROCESS INTERMEDIATES

摘要

OF THE DISCIOSURE Fluorinated alkenylamines of the formula V Formula V wherein n represents 0, 1, 2 or 3; R1 represents hydrogen or C1-C10 alkyl and Y represents (a), when n represents O, CH2F, (b), when n represents 1, CH2F or CHF2, or (c) when n represents 2 or 3, CH2F, CHF2 or CP3 are novel process intermadiates. They are obtained by hydrolysis and subsequent reduction of the corresponding alkenyl fluorinated methyl ketimine magnesium halides, which are novel compounds resulting from reaction of the corresponding alkenyl magnesium halides with the corresponding fluorinated acetonitriles. The fluorinated alkenylamines of Formula V are oxidized whilst the amino group is protected to provide, after removal of the amine protecting group, the corresponding fluorinated methyl aminoalkanoic acids which are useful pharmacological or antibacterial agents.