发明名称 |
FOERFARANDE FOER FRAMSTAELLNING AV INDOLDERIVAT |
摘要 |
Indole derivatives of the general formula (I) are disclosed: <IMAGE> (I) where R1 is H or an alkyl or alkenyl group, R2 is H, or an alkyl, alkenyl, aryl, aralkyl or cycloalkyl group; R3 is H or an alkyl group; R4 and R5 are independently H or an alkyl or propenyl group or together form an aralkylidene group; and Alk is an optionally substituted alkylene chain; and their physiologically acceptable salts and solutes. These compounds are potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner. Various methods for the production of the compounds are disclosed including a Fischer-indole cyclization process. |
申请公布号 |
FI832035(L) |
申请公布日期 |
1983.12.08 |
申请号 |
FI19830002035 |
申请日期 |
1983.06.07 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
DOWLE, MICHAEL DENNIS;COATES, IAN HAROLD |
分类号 |
C07D209/14;A61K31/40;A61K31/403;A61K31/4035;A61K31/404;A61P9/00;A61P25/04;A61P25/06;C07D209/10;C07D209/16;C07D209/18;C07D209/24;C07D209/48 |
主分类号 |
C07D209/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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