6 Alpha-methylprednisolone derivatives.

摘要

A 6a-methylprednisolone derivative of the general formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="55" wi="64" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R' is a hydrogen atom or the group
<Chemistry id="chema02" num="0002"><Image id="ia02" he="11" wi="9" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>where R<Sup>3</Sup> is a straight or once-branched chain C<Sub>1-4</Sub> alkyl group, a phenyl group or a lower alkoxy- or alkylthio-methyl group, and R<Sup>2</Sup> is a straight or once-branched chain C<Sub>1-4</Sub> alkyl group, a phenyl group or a lower alkoxy- or alkylthio-methyl group, with the proviso that when R<Sup>2</Sup> is ethyl group, R<Sup>1</Sup> is not a hydrogen atom or a propionyl group.

These compounds exhibit a strong local anti-inflammatory effect and so are useful in external anti-inflammatory preparations for the treatment of various dermal disorders and also as anti-allergic drugs for the treatment of asthma and other allergic diseases.