| 摘要 |
A process for preparing L- carnitine which comprises exposing gamma - substituted acetoacetic acid esters or amides to the fermentative enzymatic action of a microorganism which elaborates L- beta -hydroxyacyl CoA dehydrogenase [EC1.1.1.35], recovering the resulting, optically active, corresponding gamma -substituted- beta - hydroxybutyric acid derivative and converting said derivative to L- carnitine. An improvement in the process is also disclosed which comprises reacting a 4-chloro-3(R)- hydroxybutyrate with sodium iodide or bromide to produce the corresponding 4-iodo- or 4-bromo-3(R)- hydroxybutyrate, converting the 4- iodo or 4-bromo-3(R)-hydroxybutyrate to the trimethylamino-3(R)- hydroxybutyrate salt, then converting the trimethylamino-3(R)- hydroxybutyrate salt into L-carnitine inner salt. Novel chemical intermediates prepared in the processes are also disclosed; namely the 3(R) forms of <IMAGE> where R represents specified esterifying or amidifying groups and X is Cl, Br, I or OH. |
