摘要 |
Mitomycin A, mitomycin C, and porfiromycin react with amide acetals and other amide derivatives to produce amidine derivatives having antitumor activity against experimental animal tumors. The amidines derived from mitomycin C are useful intermediates in reactions with primary amines to produce both known and novel 7-amino-9a-methoxymitosanes having antitumor activity against experimental animal tumors. |