NOVEL BETA-LACTAM DERIVATIVE

摘要

3-Heterocyclylamino-ethylthio- 6-substd.-7-oxo carbapen-2-em-2-carboxylic acids and their S-oxides of formula (I) and their salts and esters are new. (R is 1-6C alkyl or 3-6C alkenyl; n is 0 or 1; and ring X is a mono- or poly-cyclic N-contg. heterocyclic gp.) (I) in which R is Et and the H atoms at C5 and C6 are trans are pref. (I) are broad-spectrum antibacterials useful as therapeutic agents in man and animals and as industrial bactericides e.g. food preservatives, disinfectants, etc. Dose is 5-500 mg/kg daily.