| 摘要 |
<p>The invention concerns hypotensive, antihypertensive and bradycardic compounds of the formula I <IMAGE> wherein Ph is unsubstituted 1,2- phenylene, or 1,2-phenylene substituted by one to three identical or different members selected from lower alkyl, lower alkoxy, lower alkylenedioxy, hydroxy, halogeno and trifluoromethyl; R1 is hydrogen, lower alkyl or amino-lower alkyl; R2 is lower alkyl or HPh-lower alkyl; and each of R3, R4 and R5 is hydrogen or lower alkyl; the amides, mono- or di-lower alkylamides, lower alkyl esters, (amino, mono- or di-lower alkylamino, carboxy or carbo-lower alkoxy)-lower alkyl esters, or salts. They can be prepared, for example by hydrolysing a compound of the general formula <IMAGE> wherein at least one of V and W is cyano, and the other is said free, amidized or esterified carboxy group.</p> |
