发明名称 |
IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF |
摘要 |
Compounds of the general formula: <IMAGE> (I) wherein X is a group of the formula: <IMAGE> m is 2 or 3; n is an integer of from 1 to 4; and R is a 5-membered heterocyclic group containing as heteroatoms a nitrogen atom and an additional oxygen or sulphur atom or up to three further nitrogen atoms; or a 6-membered heterocyclic group containing one or two nitrogen atoms; and the pharmaceutically acceptable acid addition salts thereof, are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclo-oxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis, migraine and the vascular complications of diabetes. |
申请公布号 |
DE3161260(D1) |
申请公布日期 |
1983.12.01 |
申请号 |
DE19813161260 |
申请日期 |
1981.03.03 |
申请人 |
PFIZER LIMITED;PFIZER CORPORATION |
发明人 |
CROSS, PETER EDWARD;DICKINSON, ROGER PETER |
分类号 |
C07D417/12;A61K31/415;A61P7/02;A61P43/00;C07D401/12;C07D403/12;C07D521/00;(IPC1-7):C07D401/12;A61K31/44;A61K31/50;A61K31/42;A61K31/41 |
主分类号 |
C07D417/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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