DERIVATIVES OF 3-AMINO PREGN-5-ENE,THEIR SALTS,THEIR PREPARATION,THEIR APPLICATION AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM

摘要

A compound selected from the group consisting of: 3-amino- DELTA 5-pregnenes of the formula I: (I) wherein X is selected from the group of the wavy lines indicate that the group may be in the alpha -or beta -position, R1 is selected from the group consisting of hydrogen and hydroxyalkyl or 2 to 5 carbon atoms, R2 is selected from the group consisting of hydrogen, hydroxyalkyl of 2 to 5 carbon atoms, acyl of an aliphatic carboxylic acid of 3 to 8 carbon atoms, alkoxycarbonyl of 2 to 8 carbon atoms, acyl of an alpha -amino-carboxylic acid or from a peptide of 2 to 3 amino acids of which amines may be either unsubstituted or mono-or disubstituted with alkyl of 1 to 5 carbon atoms with the proviso that R1 and R2 are not both hydrogen and that if the 3-amino group is in the beta -position, (i) when X is R1 and R2 are not both hydroxyethyl or (ii) when X is and R1 is hydrogen, R2 is not ethoxycarbonyl, the compound of the formula I wherein X is R1 is hydrogen and R2 is methyl, the 3-amino group is in the alpha -position and their non-toxic, pharmaceutically acceptable acid addition salts which are useful as stimulants of the mammalian immune system.