Azabicycloalkane derivatives, their preparation and medicaments containing them.

摘要

Compounds of formula (I), ore pharmaceutically acceptable salt thereof, or a solvent adduct or N-oxide thereof, or a solvate of any of the foregoing: <CHEM> wherein: n is 0 or 1; one of X and Y is CO and the other is NR9, R9 being hydrogen or as defined with R1; R1 is C1-6 alkoxy, C1-6 alkylthio or, together with R9 when Y is NR9, C1-2 alkylene, and one of R2, R3 and R4 is hydrogen and the other two together are C1-2 alkylenedioxy; or the other two are the same or different and are selected from hydrogen, halogen, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, carboxylic C1-7 acyl, carboxylic C1-7 acylamino, C1-6 alkylsulphonyl, C1-6 alkylsulphinyl, hydroxy, nitro, C1-6 alkylsulphonyl amino or N-C1-6 alkylsulphonyl-N-C1-6alkaylamino, or amino, aminocarbonyl, aminosulphonyl, aminosulphonylamino or N-(aminosulphonyl)-N-C1-6 alkylamino, optionally N-substituted by one or two C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4alkyl, phenyl or phen C1-4alkyl groups, any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C1-6 alkoxy or nitro groups, or optionally N-disubstituted by C4-5 polymethylene, or R1 and R2 together are C1-2 alkylenedioxy, C1-2 oxyalkylenethio, C2-3 alkyleneoxy or N-(C1-2 oxyalkylene)-N-C1-6 alkylamino; and R3 and R4 together are C1-2alkylenedioxy or R3 or R4 are same or different and are selected from the previously defined class of substituents; R5 is C1-7 alkyl, -(CH2)sR10, s being 0 to 2 and R10 being C3-8 cycloalkyl, -(CH2)tR11, t being 1 or 2 and R11 being thienyl or phenyl optionally substituted by one or two substituents selected from C1-4 alkoxy, trifluoromethyl, halogen, nitro, carboxy, esterified carboxy and C1-4 alkyl optionally substituted by hydroxy, C1-4 alkoxy, carboxy, esterified carboxy or in vivo hydrolysable acyloxy; and one of R6 and R7 when n=0 is C1-4 alkoxy, C1-4-alkoxycarbonyl, hydroxy or C1-4alkyl optionally substituted by hydroxy, C1-4 alkoxy or C1-4acyloxy, and the other is hydrogen or C1-4 alkyl or one of R6, R7 and R8 when n=1 is C1-4alkyl and the other two are the same on different and are hydrogen or C1-4alkyl, process for their preparation and compositions containing them.