| 发明名称 |
Method for preparing 8-acylthio-1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e),11(a)-trimethyl-3-benzazocines. |
| 摘要 |
<p>A method for preparing 8-acylthio-1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e), 11 (a)-trimethyl-3- benzazocines represented by general formula (I) below
<Chemistry id="chema01" num="0001"><Image id="ia01" he="30" wi="67" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R represents an alkyl group, a phenyl group or a heterocyclic group, which comprises reacting 1,2,3,4,5,6-hexahydro-2,6-methano-3.6(e),11(a)-trimethyl-3-benzazocine represented by the formula (II) below
<Chemistry id="chema02" num="0002"><Image id="ia02" he="30" wi="74" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or its salt with chlorosulfonic acid, heating the reaction product in the presence of a reducing agent, and reacting the reaction mixture with an acyl halide represented by the general formula (III)
<Chemistry id="chema03" num="0003"><Image id="ia03" he="9" wi="69" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></p> |
