| 摘要 |
<p>Novel 1,2-benzisoxazole derivatives of the formula: <CHEM> wherein R1 is hydrogen atom, a halogen atom, hydroxy group, a lower alkyl group, trifluoromethyl group, or a lower alkoxy group, R2 is hydroxy group, hydroxymethyl group, a cycloalkyl group, phenoxy group, phenylthio group, or benzyl group, R3 is hydrogen atom or benzyl group, Y is a group of the formula: <CHEM> or <CHEM> R4 is hydrogen atom or a lower alkyl group, R5 and R6 are the same or different and are each a lower alkyl group or combine together with the adjacent nitrogen atom to form a heterocyclic group, R7 is a lower alkyl group, m and n are the same or different and are each an integer of 0 to 3, sum of m and n is an integer of 1 to 4, and q and r are the same or diffferent and are each an integer of 1 to 3, and sum of q and r is an integer of 3 to 5, and a pharmaceutically acceptable acid addition salt or quaternary ammonium salt thereof, said compounds having excellent antispasmodic activities, particularly a combination of anti-cholinergic activity and musculotropic activity, and being useful as an antispasmodic agent, and a pharmaceutical composition containing said compounds (I) or their salts as an active ingredient.</p> |
