| 摘要 |
Imidazo¢1/2-a!pyridines of the formula: and their acid addition salts in which Y represents a hydrogen or halogen atom or a C1-4 alkyl radical Z represents a naphthyl radical or a radical ,in which each of X1 and X2 independently of one another is a hydrogen or halogen atom, a C1-4 alkoxy radical, a C1-6 alkyl radical or CF3, CH3S-, CH3SO2- or -NO2, and each of R1 and R2 independently of one another represents a hydrogen atom, a straight or branched C1-5 alkyl radical which is unsubstituted or substituted by one or more halogen atom, hydroxyl, -N(C1-4 alkyl)2, carbamoyl or C1-4 alkoxy radicals, an allyl radlcal, a propargyl radical, a C3-6 cycloalkyl radical, the benzyl radical, or the phenyl radical, not both R1 and R2 being being hydrogen, or -NR1R2 represents a heterocyclic ring containing from 3 to 6 carbon atoms, or a heterocyclic ring of the formula , in which X is 0, S, CHOR' or , R' being hydrogen or benzyl and R being hydrogen, a C1-4 alkyl radical, or phenyl which is unsubstituted or substituted by methoxy or a halogen atom, which may be made for the corresponding acids, have valuable pharmacological properties, especially anxiolytic, anti-anoxic, sleep-inducing, hypnotic, and anticonvulsant properties. |
