Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical formulations

摘要

Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: <IMAGE> (I) wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, aryloxy, arylalkyloxy, arylhydroxymethylene, arylcarbonyl, arylalkylcarbonyl, alkyloxy, alkylthio or a substituted cycloalkyl or cycloalkenyl group or (ii) A' is an -SO2- group and R is aryl or heterocyclyl or (iii) A is a chemical bond and R is a heterocyclyl. Some of these imidazoles and salts are novel. Methods of preparing the imidazoles are disclosed. The imidazoles and their salts are useful in the treatment or prophylaxis of thrombo-embolic conditions, shock and angina pectoris.