DETECTION OF HUMAN CANCER CELLS WITH ANTIBODIES TO HUMAN CANCER NUCLEOLAR ANTIGEN(S)

摘要

DETECTION OF HUMAN CANCER CELLS WITH ANTIBODIES TO HUMAN CANCER NUCLEOLAR ANTIGEN(S) Specific common nucleolar antigen(s) are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purified. Antibodies and antisera specific to these nucleolar antigen(s) are harvested from non-human hosts and used for detection of human cancer cells. Disclosed are (1) methods for isolating the nucleolar antigen(s), obtaining them in substantially purified form, producing the specific antibodies, obtaining them in substantially purified form, and using the antisera and antibodies induced by the nucleolar antigen(s) in diagnostic procedures for detecting human cancer cells, and (2) diagnostic kits comprising specific antibodies and antisera.