| 摘要 |
<p>This invention relates to new intermediates for the preparation of certain phthalimidines and phthalazinones. The intermediates are more particularly concerned with the preparation of 3-aryl-3-hydroxyphthalimidines which are useful as therapeutic agents. <??>The 3-aryl-3-hydroxyphthalimidines produced in accordance with the present invention are compounds of the formula: <CHEM> wherein, Y and Z are each H, alkyl, halo alkoxy, trifluoromethyl, hydroxy, alkanoyloxy, or alkanoylamino; X is F, Cl, Br or NR1R2 in which R1 and R2 are each hydrogen, alkyl, alkynyl, alkenyl, cycloalkyl, aryl or aralkyl; and R is H, alkyl, cycloalkyl, or aralkyl. </p> |
