发明名称 |
3-Formylmethyl-cephalosporins |
摘要 |
The invention provides new cephalosporins of the general formula: <IMAGE> (I) in which n=0 or 1, R4 is an amine-protecting radical, Ra5 and Rb5, which are identical or different, are hydrogen atoms or alkyl radicals, or form an alkylene radical of 2 or 3 carbon atoms, Rc5 is a hydrogen atom or an acid-protecting radical and R2 is an acid-protecting radical or a radical which can easily be removed by an enzymatic method. The compounds of formula (I) are in the form of a 3-oxoethyl-bicyclooct-2-ene or -bicyclooct-3-ene or a 3-oxoethylidenebicyclooctane if n=0, and in the form of a 3-oxoethylbicyclooct-2-ene or a 3-oxoethylidenebicyclooctane if n=1. They are useful as intermediates for the preparation of pharmaceutically active cephalosporins.
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申请公布号 |
US4415735(A) |
申请公布日期 |
1983.11.15 |
申请号 |
US19810322963 |
申请日期 |
1981.11.19 |
申请人 |
RHONE-POULENC INDUSTRIES |
发明人 |
FARGE, DANIEL;ROY, PIERRE L.;MOUTONNIER, CLAUDE;PEYRONEL, JEAN-FRANCOIS |
分类号 |
C07D501/14;A61K31/545;A61K31/546;A61P31/04;C07D501/20;C07D501/24;C07D501/26;C07D501/60;(IPC1-7):C07D501/26 |
主分类号 |
C07D501/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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