| 摘要 |
PURPOSE:A pharmaceutical for nasotracheal administration obtained by blending a physiologically active substance having immunological regulating action with a surfactant having a steroid skeleton or triterpene skeleton and having improved absorption through nasal mucosae. CONSTITUTION:A pharmaceutical for nasotracheal administration containing a surfactant, e.g. saponin or bile acid salt, having a steroid skeleton or triterpenoid skeleton in a physiologically active substance, e.g. interferon, having immunological regulating action. The administration method for the physiologically active substance having immunological regulating action is limited to an injection, but the administration by injection is inconvenient involving pain. Although nasotracheal administration is considered as the administration method other than the injection, addition of the surfactant to the physiologically active substance provides rapid absorption of the active substance through the nasal mucosae. For example, an aqueous solution is specifically sprayed into the nasal cavity, but the pharmaceutical may be formed into a freezedried powder from the viewpoint of the preservation stability and dissolved in use. The content of the surfactant is 0.01-50wt/vol% in an aqueous solution or suspension.
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