4-CYANO-2-AZETIDINONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION

摘要

4-cyano-2-azetidinone derivates s represented by the following general formula: wherein R<1> represents an amino group which may be acylated or protected, X represents H or a methoxy group, and W represents H or a sulfo group, and a process for their preparation shown by the following scheme (wherein R<2> represents an amino group which may be acylated or protected, Y represents halogen or a group represented by (wherein R<3> represents a hydrocarbyl group, and n represents 1 or 2), R<4> represents an amino group which may be acylated or protected, and other symbols are the same as defined above). Compounds (I) are utilized as advantageous intermediates for synthesizing optically active 4-substituted-2-azetidinone derivatives, and compounds (I) wherein W = SO3H are utilized as bactericides and beta -lactamase inhibitors.