Pharmaceutically active copolymers, process for their preparation and pharmaceutical compositions containing them.

摘要

The invention relates to new, pharmaceutically active copolymers with heparin-like activity, pharmaceutically acceptable salts thereof and a process for their preparation. The new copolymers comprising the units of the general formula /I/
<Chemistry id="chema01" num="0001"><Image id="ia01" he="18" wi="65" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>derived from /meth/acrylic acid or an ester thereof /X stands for hydrogen or methyl and Y is hydrogen/, units of the formula /III/
<Chemistry id="chema02" num="0002"><Image id="ia02" he="13" wi="79" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>optionally units of the general formula /II/
<Chemistry id="chema03" num="0003"><Image id="ia03" he="13" wi="78" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>/Z' is hydrogen/, and chain terminating units, formed from the units of the formulae /I/, /III/ and optionally /II/ under the conditions of copolymerization, in a statistical arrangement, and the pharmaceutically acceptable salts thereof, which contain, in addition to the above chain-members, units of the general formulae /IV/ and/or /V/
<Chemistry id="chema04" num="0004"><Image id="ia04" he="12" wi="82" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><!-- EPO <DP n="2"> --><Chemistry id="chema05" num="0005"><Image id="ia05" he="24" wi="71" file="IMGA0005.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>/X has the same meaning as defined above, and A is a cation/ satisfactorily replace the organogenic heparin, or give a synergistic combination with that.