摘要 |
<p>This invention provides compounds of the general formula (I) wherein R represents a lower alkyl group, X represents an oxygen or sulphur atom, n stands for zero or 1, Y represents a methylene, ethylene or propylene group or, when n stands for zero, Y can also represent a group of the formula - CH=CH-CH2 - (a) , in which the double-bond is trans and the carbon atom marked with an asterisk is linked to Z, and Z represents a 5-membered aromatic heterocyclic ring which contains one or more nitrogen atoms as the sole hetero atom(s), which is linked to Y via a nitrogen atom and which may be substituted by a halogen atom or a lower alkyl, lower alkoxy, aryl, cyano or carboxamido group or on adjacent carbon atoms by a group of the formula -(CH2)4- or -CH=CH-CH=CH- , (b) (c) and pharmaceutically acceptable acid addition salts thereof, a process for their manufacture and pharmaceutical preparations containing them. The aforementioned compounds and salts possess .beta.-adrenersic blocking activity and antihypertensive activity.</p> |