发明名称 Radiation sensitising compsns. contg. amino-pyrazine derivs.
摘要 <p>Growth promotion of animals and productive livestock comprises administering growth promoting amt. of quinoxaline-di-N-oxide carboxamide deriv. of formula (I) or its acid addition salt. In (I) R1 is H or 1-4C alkyl and R2 and R3 are each 1-4C alkyl or together with N atom form heterocyclic ring opt. substd. by 1-4C alkyl, the ring contains 4 or 5 C atoms and opt. O as further hetero atom; A is 1-4C alkylene. - (I) are used to combat pathogenic microorganisms in veterinary medicine esp. effective in case of diseases of respiratory tract in poultry and infections of intestinal tract and urogenital system in domestic animals and livestock. They are also used as growth promoting agents. Administration can be perorally, via the abomasum or by injection. EPAB- EP--96125 B A pharmaceutical composition useful in enhancing the therapeutic effect of radiation treatment comprising a radiation-enhancing compound of the formula (I) where each of R and R1 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C1-6 substituted alkyl or C2-6 substituted alkenyl having one or more halo, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C1-6 alkoxy, hydroxy, ethoxycarbonyl, phenyl, pyridyl, pyrimidinyl or imidazolyl substituents, or R and R1 together form a morpholine, piperazine or N-substituted piperazine ring in which the N-substituent is hydrogen, C1-6C alkyl, C1-6 hydroxyalkyl or C1-6 alkoxyalkyl; or a compound that is a pharmaceutically acceptable acid-addition salt thereof, and a pharmaceutical carrier. (12pp)</p>
申请公布号 ES8307764(A1) 申请公布日期 1983.11.01
申请号 ES19890005130 申请日期 1982.06.14
申请人 MERCK & CO., INC. 发明人
分类号 A61K31/495;C07D241/16;(IPC1-7):07D241/16;61K31/495 主分类号 A61K31/495
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