发明名称 |
Process for producing acosamine, daunosamine, 1-thioacosamine and related compounds |
摘要 |
A process for synthesizing acosamine, daunosamine and 1-thioacosamines from L-rhamnal is disclosed that can generally be characterized by Michael addition of an alkoxide or thioalkoxide to the enone formed by allylic oxidation of L-rhamnal to directly generate the 2-deoxy functionality, and stereospecific reduction of the oxime to the arabino compound which establishes configuration at C-3 and generates a compound which requires only epirmerization at C-4 to yield the desired product. The synthesis of anthracycline antibiotics incorporating these sugars or their derivatives by glycosidation of the glycone is also disclosed.
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申请公布号 |
US4413120(A) |
申请公布日期 |
1983.11.01 |
申请号 |
US19810251636 |
申请日期 |
1981.04.06 |
申请人 |
PURDUE RESEARCH FOUNDATION |
发明人 |
WHISTLER, ROY L. |
分类号 |
C07H15/04;C07H15/14;(IPC1-7):C07H1/00 |
主分类号 |
C07H15/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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