发明名称 |
NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF |
摘要 |
<p>The anthranilic acid derivative or the salt thereof represented by the general formula
wherein R 1 and R 2 are hydrogen atom, or the like; R 3 is a phenyl, cycloalkyl or bicyclic heterocyclic group which may be substituted, or the like; R 4 is a phenyl, cycloalkyl or pyridyl group which may be substituted, or the like; X 1 is an alkylene or alkenylene group which may be substituted or a bond; X 2 is the general formula -X 3 -X 4 - or -X 4 -X 3 -, wherein X 3 is a sulfur atom, an imino group or a bond, or the like; X 4 means an alkylene or alkenylene group which may be substituted or a bond; is useful for a remedy such as rheumatoid arthritis, osteoarthritis and carcinoma, because it shows MMP-13 production inhibitory effect.</p> |
申请公布号 |
EP1860098(A1) |
申请公布日期 |
2007.11.28 |
申请号 |
EP20060715640 |
申请日期 |
2006.03.14 |
申请人 |
TOYAMA CHEMICAL CO., LTD. |
发明人 |
YOKOTANI, JUNICHI;TANIGUCHI, YOICHI;HARA, EIJI;AKITSU, HITOSHI;TANAKA, HIDEHIKO;ANZAI, SHUZO |
分类号 |
A61K31/381;C07C229/58;A61K31/196;A61K31/245;A61K31/343;A61K31/351;A61K31/36;A61K31/402;A61K31/404;A61K31/415;A61K31/416;A61K31/4184;A61K31/42;A61K31/426;A61K31/428;A61K31/433;A61K31/4406;A61K31/4418;A61K31/47;A61K31/472;A61K31/5375 |
主分类号 |
A61K31/381 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|