| 摘要 |
<p>This invention relates to a new and useful process for the preparation of certain phthalimidines and more particularly with the preparation of 3-aryl-3-hydroxyphthalimidines which are useful as therapeutic agents. The 3-aryl-3-hydroxyphthalimidines produced in accordance with the present invention are compounds of the formula: <CHEM> wherein, Y and Z are each N, alkyl, halo, alkoxy, trifluoromethyl, hydroxy, alkanoyloxy, or alkanoylamino; X is F, Cl, Br, or NR1R2 in which R1 and R2 are each hydrogen, alkyl, alkynyl, alkenyl, cycloalkyl, aryl or aralkyl; and, R is H, alkyl, cycloalkyl, or aralkyl.</p> |
