ZUSAMMENSETZUNGEN DER ORTHOGONALEN LYSYL-TRNA UND AMINOACYL-TRNA SYNTHETASE PAAREN UND IHRE VERWENDUNGEN

摘要

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base condon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins and homoglutamines using these orthogonal pairs.