TRANS-5-CLORO-2-METIL-2,3,3A,12B-TETRAHIDRO-1H-DIBENZ-[2,3:6,7]OXEPINO[4,5-C]PIRROL 50% AMORFO EN BASE AL PESO TOTAL DEL COMPUESTO; PROCEDIMIENTO DE PREPARACION; COMPOSICION FARMACEUTICA; Y USO PARA EL TRATAMIENTO DE UN TRASTORNO SELECCIONADO ENTRE E

摘要

This disclosure relates to amorphous asenapine and pharmaceutically acceptable complexes, salts, solvates and hydrates thereof, to solid pharmaceutical compositions containing it, and to its use to treat central nervous system disorders, including schizophrenia and bipolar disorder. This disclosure also relates to methods and materials for preparing amorphous asenapine and pharmaceutical compositions which contain it.