发明名称 |
METHOD OF INHIBITING ALDOSE REDUCTASE ACTIVITY, COMPOSITIONS THEREFOR AND PROCESS FOR PREPARING SPIRO-FLUOROFLUOREN AND SPIRO-DIFLUOROFLUOREN COMPOUNDS |
摘要 |
Accumulation of polyols in diabetic subjects causes and/or is associated with diabetic complications. Aldose reductase inhibition prevents the production of polyols. Aldose reductase activity is inhibited with tetracyclic spiro-hydantoins, which makes these compounds useful in the treatment of complications arising from diabetes mellitus. A process for preparing said tetracyclic spiro-hydantoins by reacting a mono- or di-fluorofluorene with an excess of oxygen and a tetralkyl- or arylalkyl-trialkyl-ammonium hydroxides followed by cyclization of the reaction product with ammonium carbonate and potassium cyanide at elevated temperature is also disclosed. |
申请公布号 |
WO8303543(A1) |
申请公布日期 |
1983.10.27 |
申请号 |
WO1983US00546 |
申请日期 |
1983.04.11 |
申请人 |
ALCON LABORATORIES, INC. |
发明人 |
YORK, JR., BILLIE, MURRAY |
分类号 |
C07D233/72;C07D235/02;(IPC1-7):61K31/415;07D235/02 |
主分类号 |
C07D233/72 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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