TEMPERATURE SENSITIVE REASSORTANT VIRUSES AND A VACCINE AGAINST EQUINE INFLUENZA

摘要

A method and resulting temperature-sensitive (ts) reassortant virus produced by modifying wild-type equine influenza viruses by utilizing mutagenized human influenza viruses possessing ts lesions and shut off temperatures in the area of 37-39 C, preferably 37-38 C. When utilized as a vaccine for equines, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms while producing protection against infectious equine influenzal disease.