PREPARATION OF PYRAZINO-ISOQUINOLINE DERIVATIVES AND INTERMEDIATES THEREFOR

摘要

2-Acyl-1,3,4,6,7,11b-hexahydro-2H-pyrazino-[2,1-a]-4-isoquinoleinones having anthelmintic activity of the formula are prepared from 4-acyl-2,6-dioxopierazines by reaction with a phenethyl halide, selective reduction of one of the oxo groups and cyclization, by the novel intermediates of formula in which Y represents O or H, OH.