| 摘要 |
There are presented novel pharmaceutically active substances which inhibit the intestinal resorption of cholesterol and which accordingly can be used in the control or prevention of atherosclerosis. These active substances are benzodiazepines of the formula <IMAGE> I wherein R1 is (C1-C4)-alkyl, R2 is hydrogen or methyl, R3 and R4 each are halogen and R5 is (C3-C9)-alkylamino substituted by at least two hydroxy groups, (C3-C6)-cycloalkylamino substituted by at least one hydroxy group, glucosamino, galactosamino, mannosamino, monohydroxy-1-azetidinyl, mono- or dihydroxy-1-pyrrolidinyl or mono-, di- or trihydroxy-1-piperidinyl, and the readily hydrolyzable esters and ethers thereof, as well as pharmaceutically acceptable salts of these compounds. |
