Erythromycin D and esters thereof by fermentation.

摘要

A culture of microorganism, Nocardia sp. ATCC 39043, directly produces erythromycin D by fermentation, together with esters comprising 4 sec -O-acetylerythromycin D, 3 sec , 4 sec -di-O-acetylerythromycin D and 3 sec -O-acetyl-4 sec -O-propionylerythromycin D. The most valuable of these esters, the 3 sec , 4 sec -diacetate, is the major component of the fermentation. If erythromycin D itself is the desired product, hydrolysis of the esters is optionally carried out in the broth prior to isolation of the erythromycin D. …Erythromycin D is one of a group of macrolide antibiotics having common structural characteristics as follows: ……