| 摘要 |
Acylated macrolides I (R3=C2˜C6 alkanoy1; R4=C2˜C5 alkanoy1; R11=C2˜C3 alkanoy1) were prepd. Thus, 9-o-dichloroacetylleucomycin A5 (RfA=0.55, RfB=0.11), dissoloved in acetate, was treated with NaHSO4, stirred at room temp. for an hr., and stirred again at 60oC for 5 hrs. The mixt. was filtrated, washed, and eluted with a soln. contg. benzene:acetone=9:1 to give 18,2'-di-o-acety1-9-o-dichloroacety1-3,18-o-cycloleucomycin A5 which was treated with NH3-MeOH and dried. The resulting ext. was eluted with benzene-acetone (3:1) mixt. to give 3"-o-acetylleucomycin A5.
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