beta -Lactam antibiotics, their preparation and use

摘要

The present invention provides a compound of the formula (I): <IMAGE> (I) or a pharmaceutically acceptable salt or in-vivo hydrolyzable ester thereof wherein R1 is a hydrogen atom, an alpha -sulphonato-oxyethyl group, an alpha -sulphonato-oxypropyl group or is a group CR3R4R5 wherein R3 is a hydrogen atom or a hydroxy group; R4 is a hydrogen atom or a C1-6 alkyl group; and R5 is a hydrogen atom or a C1-6 alkyl group, a benzyl group, a phenyl group or is joined to R4 to form together with the carbon atom to which they are joined a carbocyclic ring of 5 to 7 carbon atoms; R2 is a pyrimidinyl group substituted by one two or three groups selected from nitro, halo, amino or substituted amino, and in addition may be optionally substituted by one or two C1-6 alkyl groups as the degree of substitution permits; and x is zero or one. These compounds are antibacterial agents. Their preparation and use are described.