| 主权项 |
1. A system for kidney replacement therapy, comprising:
a hemodialysis system having a controlled compliance dialysis circuit, a dialyzer with a dialysis membrane, a blood inlet end for receiving blood, a blood outlet end for allowing blood out of the dialyzer, a dialysate inlet end for receiving dialysate and a dialysate outlet end for allowing dialysate out of the dialyzer, wherein the blood and the dialysate contact different sides of the dialysis membrane; a dialysate flow loop for circulating a dialysate through a dialyzer where at least one waste species enters the dialysate; a dialysate regeneration unit containing at least one sorbent material for decreasing the concentration or conductivity of at least one waste species and releasing potassium ions to the dialysate; and a potassium management system for modifying the potassium ion concentration of the dialysate in the dialysate flow loop, generating a potassium modified fluid, the potassium-modified fluid having a potassium ion concentration or conductivity that is higher or lower than the fluid in the dialysate flow loop; wherein at least a portion of the dialysate is conveyed through the potassium management system; and wherein the potassium management system is positioned downstream of the dialysate regeneration unit; and a bypass line and a bypass regulator, wherein the bypass line is fluidly connected to the dialysate flow loop downstream of the dialysate regeneration unit and upstream of the potassium management system, and wherein the bypass line bypasses the potassium management system to downstream of the potassium management system; wherein the potassium management system is an electrodialysis cell comprising at least a concentrate flow channel, a diluate flow channel and an electrode rinse flow channel, wherein potassium ions move from the diluate flow channel to the concentrate flow channel in response to an electric field, wherein the potassium-modified fluid is generated in the diluate flow channel for addition to the dialysate flow loop. |
