1,2,3,4,4a,9b-Hexahydro-4a-piperazinylmethyl-4-dibenzofuranone or -dibenzofuranol derivatives

摘要

The present invention is dealing with compounds of the formula: <IMAGE> I and pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are identical or different and represent hydrogen, halogen, lower alkyl or alkoxy or trifluoromethyl; R5 represents hydrogen or lower alkyl, X represents hydrogen and Y represents hydroxy, or X and Y together represent oxygen and Ar represents an optionally substituted aromatic moiety, having potent anti-bronchoconstrictor properties.