发明名称 |
Small liposomes for delivery of immunogen-encoding RNA |
摘要 |
Nucleic acid immunisation is achieved by delivering RNA encapsulated within a liposome. The RNA encodes an immunogen of interest, and the liposome has a diameter in the range of 60-180nm, and ideally in the range 80-160nm. Thus the invention provides a liposome having a lipid bilayer encapsulating an 5 aqueous core, wherein: (i) the lipid bilayer has a diameter in the range of 60-180nm; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases. |
申请公布号 |
AU2016213772(A1) |
申请公布日期 |
2016.09.01 |
申请号 |
AU20160213772 |
申请日期 |
2016.08.10 |
申请人 |
NOVARTIS AG |
发明人 |
GEALL, ANDREW;VERMA, AYUSH |
分类号 |
A61K48/00;A61K9/00;A61K9/127;A61K39/00 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|