BIOCOMPATIBLE DIALYSIS FLUIDS CONTAINING ICODEXTRINS

摘要

PROBLEM TO BE SOLVED: To provide improved medical solutions that can be readily manufactured, that can remain stable and sterile under storage conditions, and that can be readily and effectively used during medical therapy, such as dialysis therapy.SOLUTION: There are provided improved glucose polymer-based solutions and methods of making the same that can be used during medical therapy, such as dialysis therapy. The glucose polymer-based solution preferably includes a first solution containing icodextrin at a pH ranging from about 1.5 to about 5.0 and a buffer solution at a pH ranging from about 7.0 to about 12.0 that are so constructed and arranged allowing the glucose polymer-based solution to be mixed prior to infusion into a patient. The glucose polymer-based solutions of the present invention can be made at physiologic pH and with minimal glucose degradation products.SELECTED DRAWING: Figure 1