| 摘要 |
The invention relates to tissue adhesives or sealants, more specifically to fibrinogen based sealants reinforced with particulate material and chemically cross-linked. More particularly, the present invention is directed to tissue sealant, adhesive, hemostat, or scaffolding material containing thrombin, fibrinogen, a biocompatible particulate material having amine functionality, and a biocompatible polymer containing aldehyde groups. The present invention is also directed to methods for the use of such materials. |
| 主权项 |
1. A tissue sealant, adhesive, hemostat, or scaffolding material, wherein said tissue sealant, adhesive, hemostat, or scaffolding material is a two-part system comprising a first solution and a second solution, comprising:
thrombin, fibrinogen, a biocompatible particulate material having amine functionality, said biocompatible particulate material is atelocollagen a biocompatible polymer containing aldehyde groups, wherein said biocompatible polymer is oxidized dextran or polyvinyl alcohol acetoacetate; and a catalyst, wherein said first solution comprises thrombin, biocompatible particulate material, and the biocompatible polymer; wherein said second solution comprises fibrinogen and the catalyst; and wherein said catalyst is DABCO. |
