Pharmaceutical composition for use in the treatment and/or the prevention of osteoarticular diseases

摘要

An intra-articular pharmaceutical composition is used for the treatment and/or the prevention of acute or chronic osteoarticular diseases and acute or chronic osteoarticular symptoms especially osteoarthritis. The composition includes a possibly adequate pharmaceutical carrier or diluent, a glycosaminoglycan, a compound activating the alpha 2 adrenergic receptor, an anti-inflammatory agent and stem cells.

主权项

1. A method for treating a chronic osteoarticular disease in a mammalian subject, the method comprising intra-articularly injecting in a joint of the subject in need thereof a pharmaceutical composition consisting of:
an effective amount of a hyaluronic acid or a derivative thereof; and an effective amount of an alpha 2 adrenergic receptor agonist selected from the group consisting of clonidine and p-aminoclonidine; wherein the pharmaceutical composition reduces joint degeneration and a progress induced by the chronic osteoarticular disease by providing a synergic decrease in articular accumulation of inflammatory liquid, a synergic reduction of joint pain or synergic improvement of joint mobility and function for two weeks or more.