Sparstolonin B based pharmaceutical agent for neuroblastoma treatment

摘要

Use of sparstolonin B in inhibition of growth and/or viability of human neuroblastoma cells is described. The sparstolonin B can be naturally derived from the Chinese herb Sparganium stoloniferum or can be synthetic. The sparstolonin B is shown to be effective both in vitro and in vivo in inhibition of growth and/or viability of neuroblastoma cells of multiple different genetic backgrounds including N-myc amplified with wild p53 neuroblastoma cells, N-myc amplified with mutated p53 neuroblastoma cells, and N-myc nonamplified neuroblastoma cells.

主权项

1. A method for inhibiting the viability of neuroblastoma cells in vitro, the method comprising contacting a neuroblastoma cell culture with sparstolonin B, wherein the sparstolonin B contacts the cells at a concentration of about 10 micromolar or greater, wherein upon contact, the neuroblastoma cells exhibit cell death.