6,9-NITRILO-PROSTAGLANDIN ANALOGUES

摘要

6 9 -NITRILO-PROSTAGLANDIN ANALOGUES" Prostaglandin I2 analogues of the general formula: II ¢wherein R1 represents a hydrogen atom, an alkyl group containing from 1 to 12 carbon atoms, an aralkyl group containing from 7 to 13 carbon atoms, a cycloalkyl group containing from 4 to 7 carbon atoms unsubstituted or substituted by at least one alkyl group containing from 1 to 4 carbon atoms, a phenyl group unsubstituted or substituted by at least one halogen atom, trifluoromethyl or phenyl group, or by at least one alkyl, alkoxy or alkylthio group containing from 1 to 4 carbon atoms, or represents a group , or , in which m represents an integer of 1 to 12, n represents an integer of 2 to 12, R6 , R8 and R9 , which may be the same or different, each represent an alkyl group containing from 1 to 4 carbon atoms, and R7 represents a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms, R2 represents a hydrogen atom, or a methyl or ethyl group, R3 represents an alkyl group containing from 1 to 4 carbon atoms, R4 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, R5 represents an alkyl group containing from 1 to 10 carbon atoms, Y represents ethylene or trans-vinylene, the hydroxy group attached to the C-ll carbon atom is in a-configuration, and the wavy line attached to the C-15 carbon atom is in .alpha.- or .beta.-configuration or a mixture thereof!and non-toxic acid addition salts thereof and, when Rl represents a hydrogen atom, non-toxic salts thereof are new compounds possessing pharmacological properties typical of the prostaglandins.